Historical Movie: The Hinge Bending Mode of Lysozyme by Bernard R. Brooks and Martin Karplus

Title: The Hinge Bending Mode of Lysozyme
Contributors: Bernard R. Brooks and Martin Karplus
Reference: Proc. Natl. Acad. Sci. USA, 1985, 82:4995-4999.

The present version is a copy of part of a 16 mm color film made in about 1985. Unfortunately some of the beauty of the original film is lost in the digital rendition. The film is of historical interest as it shows one of the early atomic simulations (in this case a normal mode study) applied to a biological problem, that of the open/closing motions found in many proteins to let substrate in, protect the active site during catalysis, and permit release of products.

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